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Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells

Received: 7 March 2018     Accepted: 24 March 2018     Published: 12 April 2018
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Abstract

The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 1)
DOI 10.11648/j.ijbecs.20180401.15
Page(s) 25-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

CASC9, Esophageal Cancer, Cell Migration, Invasion, Long Noncoding RNA

References
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Cite This Article
  • APA Style

    Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. (2018). Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. International Journal of Biomedical Engineering and Clinical Science, 4(1), 25-29. https://doi.org/10.11648/j.ijbecs.20180401.15

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    ACS Style

    Maliha Ghaffar; Sara Khodahemmati; Jintao Li; Muhammad Shahzad; Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(1), 25-29. doi: 10.11648/j.ijbecs.20180401.15

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    AMA Style

    Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int J Biomed Eng Clin Sci. 2018;4(1):25-29. doi: 10.11648/j.ijbecs.20180401.15

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  • @article{10.11648/j.ijbecs.20180401.15,
      author = {Maliha Ghaffar and Sara Khodahemmati and Jintao Li and Muhammad Shahzad and Minglian Wang and Yangjunqi Wang and Yi Zeng},
      title = {Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells},
      journal = {International Journal of Biomedical Engineering and Clinical Science},
      volume = {4},
      number = {1},
      pages = {25-29},
      doi = {10.11648/j.ijbecs.20180401.15},
      url = {https://doi.org/10.11648/j.ijbecs.20180401.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20180401.15},
      abstract = {The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells
    AU  - Maliha Ghaffar
    AU  - Sara Khodahemmati
    AU  - Jintao Li
    AU  - Muhammad Shahzad
    AU  - Minglian Wang
    AU  - Yangjunqi Wang
    AU  - Yi Zeng
    Y1  - 2018/04/12
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijbecs.20180401.15
    DO  - 10.11648/j.ijbecs.20180401.15
    T2  - International Journal of Biomedical Engineering and Clinical Science
    JF  - International Journal of Biomedical Engineering and Clinical Science
    JO  - International Journal of Biomedical Engineering and Clinical Science
    SP  - 25
    EP  - 29
    PB  - Science Publishing Group
    SN  - 2472-1301
    UR  - https://doi.org/10.11648/j.ijbecs.20180401.15
    AB  - The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.
    VL  - 4
    IS  - 1
    ER  - 

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Author Information
  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

  • School of Economics and Management, North China Electric Power University, Beijing, China

  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

  • Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

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