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Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma

Received: 16 December 2019     Accepted: 3 January 2020     Published: 13 January 2020
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Abstract

Background: Bronchial obstruction as characteristic feature of bronchial asthma (BA) can lead to gas exchange disorders. The distinction of asthma is that even in patients without clinical symptoms and almost normal spirometry parameters may have been significant gas exchange disorders including that due alveolar ventilation reducing. This study aimed to investigate lung ventilation pecularities in patients with BA. Results: Among patients with uncontrolled course of 40% have a smoking history with index (25,8 ± 8,8) pack-years. In patients with uncontrolled asthma "dead" space ventilation volume is (211 ± 8) ml, and part of the "dead" space of the tidal volume - (30,5 ± 1,5)%, which is statistically significantly greater than that rate for patients with controlled asthma - (176 ± 11) ml and (24,6 ± 0,5)%, respectively, p < 0.05. Alveolar ventilation in patients with uncontrolled disease course is lower, namely (7,3 ± 0,4) l/min. than when controlled asthma - (8,3 ± 0,2), p < 0.05. Conclusions: Lung ventilation parameters in patients with asthma without exacerbation in general slightly different from those in healthy subjects, but the effectiveness of alveolar ventilation is reduced by 14% in uncontrolled asthma due to high waste "dead" space ventilation.

Published in American Journal of Internal Medicine (Volume 8, Issue 1)

This article belongs to the Special Issue New Approaches to Manage Difficult-to-Control, Severe Asthma

DOI 10.11648/j.ajim.20200801.13
Page(s) 14-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Bronchial Asthma, Lung Ventilation, Alveolar Ventilation

References
[1] GINA Report, Global Strategy for Asthma Management and Prevention, 2019. URL: https://ginasthma.org/gina-reports/ (last accessed 08.07.2018).
[2] B. N. Lambrecht, H. Hammad, J. V. Fahy (2019). The Cytokines of Asthma. Immunity. 50 (4): 975–991. doi: 10.1016/j.immuni.2019.03.018.
[3] Lui, J. K. & Lutchen, K. R. Clin Trans Med (2017) 6: 29. https://doi.org/10.1186/s40169-017-0159-0.
[4] Brusasco V., Barisione G. (2019) Tests of Lung Function: Physiological Principles and Interpretation. In: Cogo A., Bonini M., Onorati P. (eds) Exercise and Sports Pulmonology. Springer, Cham.
[5] Yu. I. Feschenko, L. A. Iashyna, K. V. Nazarenko, S. M. Moskalenko, S. G. Opimakh, N. M. Musienko (2018). Diagnostics of hyperinflation and emphysema in patients with asthma and copd overlap on the primary and specialized levels of medical care. Ukr. Pulmonol. J. 1: 7–13.
[6] Davis M. D., Walsh B. K., Sittig S. E., Restrepo R. D. (2013) AARC clinical practice guideline: blood gas analysis and hemoximetry. Respir Care. 58: 1694-703.
[7] Quinn M, Rizzo A. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Dec 6, 2018. Anatomy, Anatomic Dead Space.
[8] Intagliata S, Rizzo A, Gossman WG. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): May 15, 2019. Physiology, Lung Dead Space.
[9] Nieves A, Cozzo A, Kosoff Z, et al. (2019). 3D airway model to assess airway dead space. Archives of Disease in Childhood - Fetal and Neonatal Edition. 104: F321-F323.
[10] Yu. I. Feschenko, L. O. Iashyna, K. V. Nazarenko, S. G. Opimakh (2017). Assessment of alveolar ventilation in patients with asthma, COPD and their combination. www.umj.com.ua, 5 (121) – IX/X 2017. URL: https://www.umj.com.ua/wp/wp-content/uploads/2017/09/4575.pdf?upload=.
[11] Michael Jaeger J., Titus B. J., Blank R. S. (2019) Essential Anatomy and Physiology of the Respiratory System and the Pulmonary Circulation. In: Slinger P. (eds) Principles and Practice of Anesthesia for Thoracic Surgery. Springer, Cham.
[12] Singh S., Kodali B. S. (2017) Volume capnography: A narrative review. Indian Anaesth Forum. 18: 33-8.
[13] Yu. I. Feschenko, L. A. Iashyna, K. V. Nazarenko, S. G. Opimakh (2017). Exercise testing influence on pulmonary ventilation parameters in patients with bronchial asthma, chronic obstructive pulmonary disease and their combination. Asthma and allergy. 2: 7–12.
[14] Chatkin, J. M., & Dullius, C. R. (2016). The management of asthmatic smokers. Asthma research and practice, 2, 10. doi: 10.1186/s40733-016-0025-7.
[15] J.-M. Tunon-de-Lara, F. Laurent, V. Giraud, et al. (2007) Air trapping in mild and moderate asthma: Effect of inhaled corticosteroids. Journal of Allergy and Clinical Immunology. 119 (3): 583–590.
[16] S. Verbanck, D. Schuermans, W. Vincken (2010). Inflammation and airway function in the lung periphery of patients with stable asthma. J. Allergy Clin Immunol. 125: 611–616.
[17] Yu. Feschenko, L. Iashyna, K. Nazarenko and Svitlana Opimakh (2018) Factors of formation of small airways obstruction and lung hyperinflation in patients with combined pathology of asthma and chronic obstructive pulmonary disease. The Pharma Innovation Journal. 7 (1): 74–78.
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    Yurii Feshchenko, Liudmyla Iashyna, Svitlana Opimakh, Maryna Polianska, Viktoria Ignatieva, et al. (2020). Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma. American Journal of Internal Medicine, 8(1), 14-18. https://doi.org/10.11648/j.ajim.20200801.13

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    ACS Style

    Yurii Feshchenko; Liudmyla Iashyna; Svitlana Opimakh; Maryna Polianska; Viktoria Ignatieva, et al. Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma. Am. J. Intern. Med. 2020, 8(1), 14-18. doi: 10.11648/j.ajim.20200801.13

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    AMA Style

    Yurii Feshchenko, Liudmyla Iashyna, Svitlana Opimakh, Maryna Polianska, Viktoria Ignatieva, et al. Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma. Am J Intern Med. 2020;8(1):14-18. doi: 10.11648/j.ajim.20200801.13

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  • @article{10.11648/j.ajim.20200801.13,
      author = {Yurii Feshchenko and Liudmyla Iashyna and Svitlana Opimakh and Maryna Polianska and Viktoria Ignatieva and Svitlana Moskalenko and Galyna Gumenuk and Inna Zvol and Nataliia Vlasova and Liudmyla Halai},
      title = {Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma},
      journal = {American Journal of Internal Medicine},
      volume = {8},
      number = {1},
      pages = {14-18},
      doi = {10.11648/j.ajim.20200801.13},
      url = {https://doi.org/10.11648/j.ajim.20200801.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200801.13},
      abstract = {Background: Bronchial obstruction as characteristic feature of bronchial asthma (BA) can lead to gas exchange disorders. The distinction of asthma is that even in patients without clinical symptoms and almost normal spirometry parameters may have been significant gas exchange disorders including that due alveolar ventilation reducing. This study aimed to investigate lung ventilation pecularities in patients with BA. Results: Among patients with uncontrolled course of 40% have a smoking history with index (25,8 ± 8,8) pack-years. In patients with uncontrolled asthma "dead" space ventilation volume is (211 ± 8) ml, and part of the "dead" space of the tidal volume - (30,5 ± 1,5)%, which is statistically significantly greater than that rate for patients with controlled asthma - (176 ± 11) ml and (24,6 ± 0,5)%, respectively, p < 0.05. Alveolar ventilation in patients with uncontrolled disease course is lower, namely (7,3 ± 0,4) l/min. than when controlled asthma - (8,3 ± 0,2), p < 0.05. Conclusions: Lung ventilation parameters in patients with asthma without exacerbation in general slightly different from those in healthy subjects, but the effectiveness of alveolar ventilation is reduced by 14% in uncontrolled asthma due to high waste "dead" space ventilation.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma
    AU  - Yurii Feshchenko
    AU  - Liudmyla Iashyna
    AU  - Svitlana Opimakh
    AU  - Maryna Polianska
    AU  - Viktoria Ignatieva
    AU  - Svitlana Moskalenko
    AU  - Galyna Gumenuk
    AU  - Inna Zvol
    AU  - Nataliia Vlasova
    AU  - Liudmyla Halai
    Y1  - 2020/01/13
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajim.20200801.13
    DO  - 10.11648/j.ajim.20200801.13
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 14
    EP  - 18
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20200801.13
    AB  - Background: Bronchial obstruction as characteristic feature of bronchial asthma (BA) can lead to gas exchange disorders. The distinction of asthma is that even in patients without clinical symptoms and almost normal spirometry parameters may have been significant gas exchange disorders including that due alveolar ventilation reducing. This study aimed to investigate lung ventilation pecularities in patients with BA. Results: Among patients with uncontrolled course of 40% have a smoking history with index (25,8 ± 8,8) pack-years. In patients with uncontrolled asthma "dead" space ventilation volume is (211 ± 8) ml, and part of the "dead" space of the tidal volume - (30,5 ± 1,5)%, which is statistically significantly greater than that rate for patients with controlled asthma - (176 ± 11) ml and (24,6 ± 0,5)%, respectively, p < 0.05. Alveolar ventilation in patients with uncontrolled disease course is lower, namely (7,3 ± 0,4) l/min. than when controlled asthma - (8,3 ± 0,2), p < 0.05. Conclusions: Lung ventilation parameters in patients with asthma without exacerbation in general slightly different from those in healthy subjects, but the effectiveness of alveolar ventilation is reduced by 14% in uncontrolled asthma due to high waste "dead" space ventilation.
    VL  - 8
    IS  - 1
    ER  - 

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Author Information
  • Department of Pulmonology, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

  • Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases, National Institute of Phthisiology and Pulmonology, Named After Feophil Gavrilovich Yanovskiy NAMS of Ukraine, Kiev, Ukraine

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